Ingrid Remy Conformation Change Erythropoietin Receptor Activation by a Ligand - Induced
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, 990 (1999); 283 Science et al. Ingrid Remy Conformation Change Erythropoietin Receptor Activation by a Ligand-Induced This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): November 29, 2013 www.sciencemag.org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/283/5404/990.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/283/5404/990.full.html#ref-list-1 , 13 of which can be accessed free: cites 22 articles This article 350 article(s) on the ISI Web of Science cited by This article has been http://www.sciencemag.org/content/283/5404/990.full.html#related-urls 100 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/cell_biol Cell Biology http://www.sciencemag.org/cgi/collection/biochem Biochemistry subject collections: This article appears in the following
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Activation of the erythropoietin receptor is not required for internalization of bound erythropoietin.
Erythropoietin (EPO) is required for the survival and expansion of red blood cell progenitor cells and supports continued differentiation of these committed progenitors to mature red blood cells. After binding to its cognate receptor, EPO promotes receptor homodimerization, activation of receptor-associated JAK2, subsequent receptor tyrosine phosphorylation, and transduction of signal. EPO is a...
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